Ozempic vs Mounjaro for Weight Loss. The Best in 2023?

People are interested in Mounjaro (Tirzepatide) and Ozempic (semaglutide) because they might help people lose weight while also controlling their diabetes well. This piece will compare Ozempic and Mounjaro for weight loss, including how they work, whether the FDA approves them, and how well they help people lose weight.

Understanding Ozempic

Understanding Semaglutide, sold under Ozempic, Wegovy, and Rybelsus, is imperative. It is a potent GLP-1 receptor agonist. In the body, it works like the hormone GLP-1, which makes you feel full and makes insulin come out after a meal.

It is unique because it can tell the brain when it’s complete, which is why the FDA approved it to help people with type 2 diabetes and weight loss. Wegovy, one of its forms, is made to help people lose weight.

One significant benefit of ozempic is that it can be taken by mouth as pills or injected. Patients can tailor their treatment to their needs and pick the best way for them, making it more manageable.

Mounjaro: A drug that does two things

Tirzepatide is sold under the name Mounjaro, which is different. Mounjaro creates two processes, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide).

GIP, related to GLP-1, helps control insulin levels and makes you feel full. Mounjaro is now known as a promising weight control drug because it works in so many different ways.

It’s important to know that the FDA has only approved it for controlling type 2 diabetes. This means that using it to lose weight is not on the label. Also, Mounjaro is only offered in the form of an injection.

Ozempic vs Mounjaro for Weight Loss

What does the study say? Olympic vs. Mounjaro to Lose Weight

“Mounjaro vs. Ozempic for weight loss,” a recent study, directly compared how well they helped people lose weight. The results of an investigation in 2023 show that Mounjaro might become the best at helping people lose weight.

But it’s essential to remember an important point when comparing Mounjaro and Ozempic Weight Loss: the amounts of Tirzepatide and Semaglutide given to study subjects were very different. If more Mounjaro had been given, the results might have been different in its favor.

If the same amount of Semaglutide had been given to both groups, the difference in weight loss might not have been as noticeable.

It’s also important to remember that these studies mainly looked at people with type 2 diabetes. This means that the results can’t be used with groups of people who don’t have diabetes.

How long does it take to see weight loss in Mounjaro vs Ozempic?

Tirzepatide (Mounjaro): Research has shown that tirzepatide can cause significant weight loss (approx. 25%) in just 28 weeks.

In another study, individuals who took either medication experienced an average weight loss of 15% to 20% of their initial body weight over 72 weeks or about 16 and a half months.

Semaglutide (Ozempic): studies conducted by the manufacturer over 68 weeks show that, on average, adults using semaglutide lost about 15% of their body weight.

Ozempic vs Mounjaro for Weight Loss

Mounjaro vs Ozempic for Weight Loss: Cost Effectiveness

The cost difference between Ozempic and Mounjaro is not significant. Here’s the cost for Mounjaro vs Ozempic vs Wegovy.

On average, in the United States:

  • Ozempic costs approximately $1,000 per month.
  • Mounjaro costs approximately $1,025 per month.
  • Wegovy, another brand for Semaglutide, starts at approximately $1,212 per month.

Reducing Out-of-Pocket Costs

If you qualify, there are several ways to lower your out-of-pocket costs:

Insurance coverage can help cover some of the expenses. Discount coupons and copay cards may be available to reduce costs.

*These are the prices when writing this article; prices may vary in the future.

Ozempic vs Maunjaro Weight Loss: Side Effects

Common side effects of Ozempic

  • Gastrointestinal: Nausea, vomiting, diarrhea, mild stomach pain
  •  Fatigue: May occur initially but usually improves with time
  •  Changes in facial appearance
  •  Rebound weight gain: If Semaglutide, i.e., Ozempic, is stopped abruptly.

Additional Side Effects

  • Low blood sugar: Rare but higher risk when used with other blood sugar-lowering medications.
  • Vivid dreams May be related to weight loss.
  • Hair loss
  • Pancreatitis: Potentially life-threatening
  • Gallbladder disease
  • Kidney damage: More common in severe cases, especially with pre-existing kidney problems
  • Allergic reactions: Rare but essential to report to a healthcare provider.

Mounjaro can cause these side effects

  • Getting nauseous
  • Vomiting (less usual but possible)
  • Constipation
  • Loss of appetite
  • Stomach pain
  • Feeling tired
  • Hypoglycemia, or low blood sugar, especially when taken with sulfonylurea drugs.
  • Heart rate went up. Higher levels of pancreatic amylase and lipase in the blood

It’s important to remember that the studies we talked about earlier were only about people with type 2 diabetes. It’s possible that these results don’t apply to people who don’t have diabetes. People who don’t have diabetes may have different reactions to these medicines because their metabolisms are different.

Which is better for weight loss: Ozempic or Mounjaro?

It’s not easy to choose between Ozempic and Mounjaro if you want to lose weight. Both drugs work in different ways and are given in different ways. A new study points to Tirzepatide as a possible weight loss superstar, but different dosages must be considered.

People and healthcare professionals must work together to make treatment plans that fit each person’s wants and goals so that they can make an informed choice.

It may take more research and tweaking based on individual patient situations before we can say which drug is better at fighting weight gain.


  1. Is there a weight loss drug that works better than Ozempic?

A study from 2023 looked at Ozempic and Mounjaro as weight loss aids. The results showed that Mounjaro might work better than Ozempic.

  1. What might happen if I take Ozempic and Mounjaro simultaneously?

It is not suggested that you take Mounjaro (tripeptide) with Ozempic (semaglutide) or any other drug that raises incretin hormones like GLP-1 and GIP. This can make the bad results worse. Both drugs may also make it harder for other mouth medicines to work.

  1. What is the difference in how much Ozempic and Mounjaro take to lose weight?

Ozempic: Take 0.25 mg of Ozempic weekly for the first four weeks. The most Ozempic that should be taken in a week is 2 mg.

Mountain: For the first four weeks, you should take 2.5 mg of Mountain once a week. The most Mounjaro that should be taken in a week is 15 mg.

  1. Will I gain weight back if I stop taking Ozempic?

You might eat more to feel full, which could make you regain weight.

  1. Does Mounjaro make you lose your hair?

Currently, there is no proof climbing the Olympics, Wegovy, or Mounjaro causes hair loss. On the other hand, losing weight quickly can stress the body and make hair fall out for a few months.


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